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New pH-Sensetive, Food Grade Enteroguard coating. S-Adenosyl Methionine. 400 mg (net yield) SAM-e from 800 mg SAM-e Tosylate Disulfate. Highest Concentration of Active S,S Form. Promotes:. Joint Strength. Liver Detoxification. Mood and Brain Function. Enteric-Coated Tablets. Gluten Free. Vegan/Vegetarian. Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form. Found in all living cells, SAM-e is ametabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processes without chemical solvents to preserve 68-80% (S,S) SAM-e, the highest active level available. SAM-e has been clinically shown to have the following benefits:. Joint Strength. SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism. SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopramine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver. SAM-e supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transerase), which are substances important for liver function, including phase II detoxification. EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coatingthat resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.