Jerome (c. 345-420) was one of the greatest biblical scholars of antiquity. Among his achievements was his Latin translation of the Bible "according to the Hebrew," or iuxta Hebraeos. In this study, Adam Kamesar considers the origin of this project through an analysis of the Quaestiones Hebraicae in Genesim, a commentary on the book of Genesis published at approximately the same time as the first installments of the translation. Providing a look at the man and the work behind one of the most important Bibles in the history of the West, this study will be of keen interest to classicists, biblical scholars, patristics scholars, theologians, medievalists, and ancient historians.