Over the last decade, the United States' position as the world's most powerful state has appeared increasingly unstable. The US invasions of Afghanistan and Iraq, non-traditional security threats, global economic instability, the apparent spread of authoritarianism and illiberal politics, together with the rise of emerging powers from the Global South have led many to predict the end of Western dominance on the global stage. This book brings together scholars from international relations, economics, history, sociology and area studies to debate the future of US leadership in the international system. The book analyses the past, present and future of US hegemony in key regions in the Asia-Pacific, Latin America, Middle East, Europe and Africa - while also examining the dynamic interactions of US hegemony with other established, rising and re-emerging powers such as Russia, China, Japan, India, Turkey and South Africa. American Hegemony and the Rise of Emerging Powers explores how changes in the patterns of cooperation and conflict among states, regional actors and transnational non-state actors have affected the rise of emerging global powers and the suggested decline of US leadership. Scholars, students and policy practitioners who are interested in the future of the US-led international system, the rise of emerging powers from the Global South and related global policy challenges will find this multidisciplinary volume an invaluable guide to the shifting position of American hegemony.