Of all the agents to promote healthy lipoprotein metabolism*, niacin has the longest clinically documented record, beginning in 1955 and continuing today. Only niacin in the form of nicotinic acid has demonstrated these effects. Traditional, or plain niacin usage has been limited particularly by so-called "nuisance" side effects including skin flushing associated with tingling and warmth. ENDUR-ACINÂ®, owing to its unique extended release formulation, eliminates for most individuals the unpleasant skin flushing effect that occurs when taking niacin. ENDUR-ACINÂ® utilizes a unique wax-matrix process that ensures uniform, continuous release of niacin from the tablet during its 6 - 8 hour transit time through the digestive system. This greatly reduces gastrointestinal upset and gut irritation associated with the buildup of localized concentrations of niacin and skin irritations associated with a rapid rise in blood levels. ENDUR-ACINÂ® is usually well tolerated in single doses of 500 - 750 mg. Higher single doses can increase the likelihood of flushing, and can therefore be divided into a twice daily regimen to minimize the chance of side effects. Do not use ENDUR-ACINÂ® if you have a know hypersensitivity to niacin, or active liver disease. Use of any niacin for promoting healthy cholesterol levels within normal limits should always be physician supervised. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.